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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

hERG potassium channel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (6) Potassium Channel (43) Sodium Channel (6) TRP Channel (1) 5-HT Receptor (2) Adrenergic Receptor (1) Antibiotic (1) Apoptosis (1) Autophagy (1) Bacterial (5) Caspase (1) CCR (1) Cytochrome P450 (2) Dipeptidyl Peptidase (1) Dopamine Receptor (1) Endogenous Metabolite (1) Glutathione Peroxidase (1) GPR119 (1) GPR68 (1) Histamine Receptor (4) Histone Demethylase (1) HSP (2) iGluR (4) Interleukin Related (1) mAChR (1) Na+/Ca2+ Exchanger (1) Opioid Receptor (1) P-glycoprotein (1) p38 MAPK (1) Parasite (2) Phosphodiesterase (PDE) (1) Protease Activated Receptor (PAR) (1) Sigma Receptor (1) TNF Receptor (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (17) Endocrinology (5) Infection (7) Inflammation/Immunology (12) Metabolic Disease (5) Neurological Disease (15)

By Targets:

Calcium Channel (6)

Potassium Channel (43)

Sodium Channel (6)

TRP Channel (1)

5-HT Receptor (2)

Adrenergic Receptor (1)

Antibiotic (1)

Apoptosis (1)

Autophagy (1)

Bacterial (5)

Caspase (1)

CCR (1)

Cytochrome P450 (2)

Dipeptidyl Peptidase (1)

Dopamine Receptor (1)

Endogenous Metabolite (1)

Glutathione Peroxidase (1)

GPR119 (1)

GPR68 (1)

Histamine Receptor (4)

Histone Demethylase (1)

HSP (2)

iGluR (4)

Interleukin Related (1)

mAChR (1)

Na+/Ca2+ Exchanger (1)

Opioid Receptor (1)

P-glycoprotein (1)

p38 MAPK (1)

Parasite (2)

Phosphodiesterase (PDE) (1)

Protease Activated Receptor (PAR) (1)

Sigma Receptor (1)

TNF Receptor (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (17)

Endocrinology (5)

Infection (7)

Inflammation/Immunology (12)

Metabolic Disease (5)

Neurological Disease (15)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Potassium Channel Na+/K+ ATPase Chloride Channel Calcium Channel HCN Channel CRAC Channel TRP Channel Sodium Channel Piezo Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15551

E-4031

3 Publications Verification

Potassium Channel Cardiovascular Disease

E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies .

E-4031 3 Publications Verification	Potassium Channel	Cardiovascular Disease
E-4031 is a selective *hERG* potassium channel blocker for use in class III anti-arrhythmic studies .

HY-153219A

P-CAB agent 2	Potassium Channel	Endocrinology
P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H ⁺/K ⁺-ATPase activity with an IC₅₀ value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC₅₀ value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion .

HY-153219

P-CAB agent 2 hydrochloride	Potassium Channel	Endocrinology
P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H ⁺/K ⁺-ATPase activity with an IC₅₀ value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC₅₀ value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion .

HY-108594

PD-118057	Potassium Channel	Metabolic Disease
PD-118057 is a **hERG channel** activator without causing hERG blockade. PD-118057 activates **hERG channel** to suppress changes in membrane excitability .

HY-132201

MK-8153	Potassium Channel	Metabolic Disease
MK-8153 is a potent, selective and orally active inhibitor of *renal outer medullary potassium channel* (ROMK), with IC₅₀*s of 5 nM, 34 μM for ROMK electrophysiology (EP) and hERG* EP, respectively. MK-8153 can be used as the diuretic/atriuretic .

HY-108586

NS3623	Potassium Channel	Neurological Disease
NS3623 is an activator of human ether-a-go-go-related gene (hERG1/K_V11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels .

HY-124702

ICA-105574	Potassium Channel	Cardiovascular Disease
ICA-105574 is a potent and efficacious *hERG* channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC₅₀ value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2 .

HY-B2136

Tannic acid

2 Publications Verification

Potassium Channel Inflammation/Immunology Cancer

Tannic acid is a novel hERG channel blocker with IC₅₀ of 3.4 μM.
HY-N7511

O-Nornuciferine

Potassium Channel Endogenous Metabolite Metabolic Disease

O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor .

Tannic acid 2 Publications Verification	Potassium Channel	Inflammation/Immunology Cancer
Tannic acid is a novel **hERG channel blocker with IC₅₀** of 3.4 μM.

O-Nornuciferine	Potassium Channel Endogenous Metabolite	Metabolic Disease
O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent *hERG* channel inhibitor .

HY-12082A

GSK369796 Dihydrochloride	Potassium Channel Parasite	Infection
GSK369796 Dihydrochloride is an affordable and effective antimalarial and inhibits **hERG potassium ion channel repolarization with an IC₅₀** of 7.5 μM.

HY-118172

PD-307243

Potassium Channel Cardiovascular Disease

PD-307243 is a hERG channel activator. PD-307243 can be used for research of arrhythmias .

PD-307243	Potassium Channel	Cardiovascular Disease
PD-307243 is a **hERG channel** activator. PD-307243 can be used for research of arrhythmias .

HY-P5177

GsAF-II	Sodium Channel Potassium Channel	Neurological Disease
GsAF-II is a peptide toxin that blocks hERG1 subtype potassium channels in a voltage-dependent manner. GsAF-II blocks Nav1.x subtype sodium channels .

HY-16915

RPR-260243 1 Publications Verification	Potassium Channel	Cardiovascular Disease
RPR-260243, a potent activator of human ether-a-go-go-related gene (hERG), slows deactivation and attenuates inactivation of hERG1 channels. RPR260243-modified HERG currents are inhibited by Dofetilide (IC₅₀=58 nM). RPR260243 displays no activator-like effects on other voltage-dependent ion channels, including the closely related ERG3 K+ channel . RPR-260243 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111747

TBAJ-587	Bacterial	Infection Cardiovascular Disease
TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC₉₀s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization .

HY-112075

Lidoflazine	Potassium Channel Calcium Channel	Cardiovascular Disease
Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K ⁺ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia .

HY-120375

LUF7346

Potassium Channel Cardiovascular Disease

LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC₅₀ of 35.6 ± 3.2 nM .

LUF7346	Potassium Channel	Cardiovascular Disease
LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC₅₀ of 35.6 ± 3.2 nM .

HY-113673

A-935142	Potassium Channel	Cardiovascular Disease
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization .

HY-124687

ROMK-IN-32	Potassium Channel	Cardiovascular Disease
ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC₅₀ of 35 nM. ROMK-IN-32 also inhibits hERG with an IC₅₀ of 22 μM .

HY-B1482

Mesoridazine benzenesulfonate TPS-23 benzenesulfonate
Mesoridazine (TPS-23) benzenesulfonate, a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine benzenesulfonate is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC₅₀ of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine benzenesulfonate can be used for the research of schizophrenia, as well as certain other psychiatric disorders .

HY-B1482A

Mesoridazine TPS-23
Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC₅₀ of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders .

HY-N5006

Guanfu base G	Potassium Channel	Cardiovascular Disease
Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits *HERG* channel current with an IC₅₀ of 17.9 μM .

HY-B0369AS

Orphenadrine-d3 citrate	iGluR	Neurological Disease
Orphenadrine-d₃ (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

HY-A0148

Halofantrine SKF-102886 free base; WR-171669
Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum . Halofantrine blocks *HERG* potassium channels .

HY-A0148A

Halofantrine hydrochloride SKF-102886; WR-171669 hydrochloride	Parasite	Infection
Halofantrine hydrochloride (SKF-102886) is a blocker of delayed rectifier potassium current via the inhibition of human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial compound .

HY-122167

L-869298	Phosphodiesterase (PDE)	Inflammation/Immunology
L-869298 is a potent and selective PDE4 inhibitor with an IC₅₀ of 0.5 nM for PDE4A. L-869298 shows less active against hERG potassium channel .

HY-P1440A

BeKm-1 TFA	Potassium Channel
BeKm-1 TFA is a potent and selective KV11.1 (hERG) channel blocker. BeKm-1 TFA is selective for KV11.1 over a panel of 14 other potassium channels. BeKm-1 TFA dose-dependently prolongs QTc interval in isolated rabbit heart.

HY-100545

BAPTA-AM Maximum Cited Publications 48 Publications Verification	Potassium Channel	Cardiovascular Disease
BAPTA-AM is a well-known membrane permeable Ca ²⁺ chelator. BAPTA-AM inhibits *hERG* channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC₅₀s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .

HY-101622

5-HT6/7 antagonist 1	5-HT Receptor Dopamine Receptor
5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.

HY-14848

Naluzotan PRX 00023	5-HT Receptor Potassium Channel	Neurological Disease
Naluzotan is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC₅₀ and K_i of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak **hERG K ⁺ channel** blocker, with IC₅₀ of 3800 nM.

HY-146380

S1427	Histone Demethylase	Cancer
S1427 is a tranylcypromine-derived LSD1 inhibitor with the IC₅₀ of 390 nM and K_i of 80 nM. S1427 exhibits desirable hERG channel inhibition and microsomal stability profiles. Inhibition of LSD1 partially reduces the proliferation of cancer cells .

HY-B0480

Brompheniramine maleate 1 Publications Verification (±)-Brompheniramine maleate	Histamine Receptor mAChR Potassium Channel Sodium Channel Calcium Channel	Neurological Disease Inflammation/Immunology Endocrinology
Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a K_d of 6.06 nM. Brompheniramine maleate can block the **hERG channels*, calcium channels, and sodium channels* with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research .

HY-B0480A

Brompheniramine (±)-Brompheniramine
Brompheniramine ((±)-Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a K_d of 6.06 nM. Brompheniramine can block the **hERG channels*, calcium channels, and sodium channels* with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research .

HY-P5795

GsAF-I	Sodium Channel Potassium Channel	Neurological Disease
GsAF-I is a potent Na_v and *hERG1* channels blocker with IC₅₀s of 0.36, 0.6, 1.28, 0.33, 1.2, 0.04 and 4.8 μM against Na_v1.1, Na_v1.2, Na_v1.3, Na_v1.4, Na_v1.6, Na_v1.7 and hERG1, respectively .

HY-B1167

Ajmaline Cardiorythmine; (+)-Ajmaline	Sodium Channel	Cardiovascular Disease
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC₅₀ of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia .

HY-100238

Antihistamine-1
Antihistamine-1 is a H1-antihistamine (K_i=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and **hERG channel with IC₅₀**s of 5.4 and 0.8 μM, respectively.

HY-143315

Protease-Activated Receptor-1 antagonist 3	Protease Activated Receptor (PAR)	Cardiovascular Disease
Protease-Activated Receptor-1 antagonist 3 is a potent protease-activated receptor-1 antagonist with an IC₅₀ value of 7 nM. Protease-Activated Receptor-1 antagonist 3 shows binding affinity for hERG K ⁺ channel with an IC₅₀ value of 9 µM .

HY-116838

TAM-16	Bacterial	Infection
TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC₅₀ value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel .

HY-103309

ML218	Calcium Channel	Neurological Disease
ML218 is a potent, selective and orally active *T-type Ca ²⁺ channels* (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC₅₀s of 310 nM and 270 nM for Cav3.2 and Cav3.3*, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, K_ATP or hERG* potassium channels. ML218 can penetrate the blood-brain barrier .

HY-103309A

ML218 hydrochloride	Calcium Channel	Neurological Disease
ML218 hydrochloride is a potent, selective and orally active *T-type Ca ²⁺ channels* (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC₅₀s of 310 nM and 270 nM for Cav3.2 and Cav3.3*, respectively. ML218 hydrochloride inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 hydrochloride has no significant inhibition of L- or N-type calcium channels, K_ATP or hERG* potassium channels. ML218 hydrochloride can penetrate the blood-brain barrier .

HY-14186

KVI-020 WYE-160020	Potassium Channel	Cardiovascular Disease
KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC₅₀ of 480 nM. KVI-020 can inhibits *hERG, with an IC₅₀* of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research .

HY-16916

NS1643 1 Publications Verification	Potassium Channel Autophagy	Cancer
NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K ⁺ channels with an EC₅₀ of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells .

HY-A0236A

Aprindine hydrochloride	Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-13044

ADL-5859 hydrochloride 1 Publications Verification	Opioid Receptor Potassium Channel Cytochrome P450	Neurological Disease Inflammation/Immunology
ADL-5859 hydrochloride (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an K_i and an EC₅₀ value of 0.84 and 20 nM, respectively. ADL-5859 hydrochloride also shows inhibitory activity to **hERG channel with an IC₅₀** value of 78 μM. ADL-5859 hydrochloride can be used for the research of pain .

HY-B1193

Terfenadine 2 Publications Verification (±)-Terfenadine; MDL-991	Potassium Channel Histamine Receptor Na+/Ca2+ Exchanger Caspase Apoptosis	Inflammation/Immunology Endocrinology Cancer
Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of *hERG* with an IC₅₀ of 204 nM . Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca ²⁺ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 .

HY-12532

Astemizole 4 Publications Verification R 43512	Histamine Receptor Potassium Channel	Inflammation/Immunology Endocrinology
Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG K ⁺ channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole has antipruritic effects .

HY-12533

Disopyramide 1 Publications Verification Dicorantil; SC-7031	Sodium Channel Potassium Channel	Cardiovascular Disease
Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .

HY-134494

MS48107	GPR68	Neurological Disease
MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice .

HY-12533A

Disopyramide phosphate Dicorantil phosphate; SC-7031 phosphate
Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action .

HY-153952

Immuno modulator-1	TNF Receptor Interleukin Related Potassium Channel	Inflammation/Immunology Cancer
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC₅₀ values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows *hERG* potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM .

HY-147691

MPO-IN-5	Glutathione Peroxidase Potassium Channel	Inflammation/Immunology
MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC₅₀ values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (k_inact/K_i) of 23000 M ⁻¹s ⁻¹ .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2136

Tannic acid 2 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Liliaceae Ketones, Aldehydes, Acids Phenols Polyphenols Polygonatum odoratum (Mill.) Druce Inflammation/Immunology Disease Research Fields Cancer	Potassium Channel
Tannic acid is a novel **hERG channel blocker with IC₅₀** of 3.4 μM.

HY-N7511

O-Nornuciferine	Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields	Potassium Channel Endogenous Metabolite
O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent *hERG* channel inhibitor .

HY-B1167

Ajmaline Cardiorythmine; (+)-Ajmaline	Apocynaceae Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Rauvolfia serpentina Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids	Sodium Channel
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC₅₀ of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia .

HY-N1483

Guanfu base A	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields	Potassium Channel
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a K_i of 1.20 μM in human liver microsomes (HLMs) and a K_i of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (K_i of 0.38 μM) and dog (K_i of 2.4 μM) microsomes . Guanfu base A also inhibits *HERG* channel current .

HY-N5006

Guanfu base G	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields Indole Alkaloids	Potassium Channel
Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits *HERG* channel current with an IC₅₀ of 17.9 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0369AS

Orphenadrine-d3 citrate
Orphenadrine-d₃ (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

HY-103309S

ML218-d9

ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].

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